Basic Information

Symbol
hsa-mir-134
RNA class
miRNA miRNA hairpin
Alias
MIR134 MicroRNA 134 Hsa-MiR-134-5p Hsa-Mir-134 MIRN134 Hsa-Mir-134_pre Hsa-MiR-134-3p MIMAT0026481 MIMAT0000447 MI0000474 Mir-134
Location (GRCh38)
11:122152229-122152308
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-134
Sequence length
73 nt
GC content
0.6027

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.00 kcal/mol
Thermodynamic ensemble
Free energy: -36.72 kcal/mol
Frequency: 0.0618
Diversity: 10.20
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((..((((((((.((.(((.((((((((.....))))...)))).)))..)).))))))))..))))).
Thermodynamic Ensemble Prediction
.(((((,.((((((((,{(.(((.(((({,{{({...})))...)))).)))..}),)})))))),.))))).
Forensic Context

A study in young human patients with acute coronary syndrome (ACS) demonstrated that plasma levels of the mir-134 were significantly down-regulated (5-fold) in patients with ST-segment elevated myocardial infarction (STEMI) compared to healthy controls, with its expression inversely correlated with plasma troponin I levels and showing a discriminatory power (AUC=0.796) for STEMI diagnosis [Tong et al. DOI:10.3390/ijms19051467]. In human skin, the mir-134 was found to be up-regulated four days post-burn in deep partial thickness burn skin compared to normal skin and was also up-regulated in burn hypertrophic scar tissue, while a separate investigation reported its up-regulation in heat-shocked skin epidermal stem cells six hours post-burn [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that 174 mature exosomal miRNAs were differentially expressed in cardiac tissue following acute myocardial infarction, with in vitro validation showing that mimics of 19 out of 20 selected miRNAs, including the mir-134, significantly reduced hypoxic stress-induced cell death in primary cardiomyocytes [Jung et al. DOI:10.3390/biomedicines12020430]. In a rat model of Alzheimer's disease, elevated brain levels of the mir-134 were significantly downregulated by treatment with astaxanthin-loaded invasomes, which concurrently improved memory and modulated the SIRT-1/BDNF/GSK-3β signaling pathway [Kandeil et al. DOI:10.1007/S12035-025-05241-5].