Forensic Context

A study in mice demonstrated that 174 mature miRNAs were differentially expressed in cardiac exosomes following acute myocardial infarction, and in vitro validation showed that transfection with mimics of 19 selected miRNAs, including mmu-miR-149-3p, significantly reduced hypoxic stress-induced cell death in primary cardiomyocytes [Jung et al. DOI:10.3390/biomedicines12020430]. In human skin, the miR-134-3p was found to be upregulated four days post-burn in deep partial thickness burn skin compared to normal skin and was also upregulated in burn hypertrophic scar tissue [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the miR-134-3p was significantly up-regulated (2.22 fold) in the nucleus accumbens of animals with chronic methamphetamine-induced addiction compared to those receiving an acute treatment, as validated by qPCR [Sim et al. DOI:10.1007/S11011-017-0061-X]. In humans, a separate investigation of serum microRNAs in marathon runners found that the miR-134-3p showed no significant correlation with cardiac troponin T levels following strenuous exercise [Shirvani Samani et al. DOI:10.3390/jcm11010005].