Forensic Context

A study in young human patients with acute coronary syndrome demonstrated that plasma the miR-134-5p was significantly down-regulated (5-fold) in ST-segment elevated myocardial infarction patients compared to healthy controls, showing a discriminatory power with an area under the curve of 0.796 and an inverse correlation with plasma troponin I levels [Tong et al. DOI:10.3390/ijms19051467]. In human skin burn and scarring research, the miR-134-5p was found upregulated four days post-burn in deep partial thickness burn skin versus normal skin and in burn hypertrophic scar tissue, and it was also upregulated six hours post-burn in heat-shocked skin epidermal stem cells [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the insertion allele of the rs3036297 polymorphism in the HSPA1B gene is associated with a lower risk of sudden cardiac death (SCD) and functions by creating a binding site for miR-134-5p, which negatively regulates HSPA1B expression [Yang et al. DOI:10.1016/J.Forsciint.2020.110637].