A study in humans identified the miR-1-5p as a cardiac-specific microRNA deregulated in patients with stable coronary artery disease, acute coronary syndrome, and acute myocardial infarction [Tong et al. DOI:10.3390/ijms19051467]. A study in humans identified the miR-1-5p as significantly upregulated in the plasma of patients with coronary artery disease compared to normal controls, demonstrating its potential as a diagnostic biomarker [Zhong et al. DOI:10.1002/jcla.23020].