Forensic Context

A study in mice demonstrated that the miR-135b-5p is the most significantly downregulated miRNA after traumatic spinal cord injury, where it forms a verified regulatory axis with circAbca1 and KLF4, and its inhibition of KLF4 suggests a neuroprotective role [Wang et al. DOI:10.4103/1673-5374.308100]. In human forensic science, the miR-135b-5p shows semen specificity and high abundance in normal semen but exhibits significantly down-regulated and dispersed expression in various infertile semen samples, which impacts its discriminative power for body fluid identification [Tian et al. DOI:10.1016/j.fsigen.2017.12.010].