Basic Information

Symbol
hsa-mir-137
RNA class
miRNA miRNA hairpin
Alias
MIR137 MicroRNA 137 Hsa-Mir-137 MiR-137 Hsa-MiR-137 MIRN137 Hsa-Mir-137-P1-V2_pre Hsa-Mir-137-P1-V1_pre Hsa-MiR-137-5p Hsa-MiR-137-3p MIMAT0037310 MIMAT0000429 MI0000454
Location (GRCh38)
1:98046070-98046171
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-137
Sequence length
102 nt
GC content
0.4902

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.60 kcal/mol
Thermodynamic ensemble
Free energy: -49.58 kcal/mol
Frequency: 0.0404
Diversity: 7.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(.((.((((((((((((((..(((.(((((((((((((.((((((((.....)).))))))))))))))))))).)))..)))))))))))..))).))).
Thermodynamic Ensemble Prediction
.(.((.((((((((((((((..(((.((((((((((((,{((((((((.....))},)))))))))))))))))).)))..)))))))))))..))).))).
Forensic Context

A study in mice demonstrated that the mir-137 is significantly down-regulated in the traumatized cortex during secondary contusion expansion following controlled cortical impact-induced traumatic brain injury, as validated by qRT-PCR [Meissner et al. DOI:10.1089/neu.2015.4077]. The review literature notes that the mir-137 is a therapeutic target in schizophrenia, where it targets genes including NRG2/3, SYN2/3, ATXN1, ERBB4, GSK3B, FZD3, and PTGS2 [Das et al. DOI:10.1080/21655979.2021.2003667].