Basic Information

Symbol
hsa-mir-10a
RNA class
miRNA miRNA hairpin
Alias
MIR10A MicroRNA 10a Hsa-MiR-10a-3p Hsa-MiR-10a-5p Hsa-Mir-10a MIRN10A Hsa-Mir-10-P1c-V2_pre Hsa-Mir-10-P1c-V1_pre MIMAT0000253 MIMAT0004555 MI0000266 MiRNA10A Mir-10a
Location (GRCh38)
17:48579838-48579947
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-10a
Sequence length
110 nt
GC content
0.3909

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.00 kcal/mol
Thermodynamic ensemble
Free energy: -36.12 kcal/mol
Frequency: 0.0323
Diversity: 7.41
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((.((((..((((((((.((((.(((((.((((((((((................)))))))))).))))))))).))))))))..))))...))).........
Thermodynamic Ensemble Prediction
....{((.((((..((((((((.((((.(((((.((((((((((...,.,....}.}...)))))))))).))))))))).))))))))..))))...))}.........
Forensic Context

A study in humans demonstrated that the mir-10a is a semen-specific miRNA marker with high abundance in normal semen, but its expression is significantly down-regulated and dispersed in infertile semen samples, and an overlap in expression between normal semen and menstrual blood was observed [Tian et al. DOI:10.1016/j.fsigen.2017.12.010]. Research evaluating species specificity found that the mir-10a showed no expression in animal buccal swabs that fell within the human semen expression range, indicating specificity for human semen when tested against these animal materials [Peng et al. DOI:10.1016/j.forsciint.2019.04.036]. A study in rhesus macaques (Macaca mulatta) demonstrated that the mir-10a was utilized as a feature in a dose-prediction model developed from serum miRNA expression data at Day 21 following whole thorax irradiation [May et al. DOI:10.1038/s41598-022-16316-x].