Basic Information

Symbol
hsa-mir-139
RNA class
miRNA miRNA hairpin
Alias
MIR139 MicroRNA 139 Hsa-MiR-139-3p Hsa-MiR-139-5p Hsa-Mir-139 MIRN139 Hsa-Mir-139_pre MIMAT0004552 MIMAT0000250 MIR139-3p MI0000261 Mir-139
Location (GRCh38)
11:72615063-72615130
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Postmortem interval inference Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-139
Sequence length
68 nt
GC content
0.5882

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.60 kcal/mol
Thermodynamic ensemble
Free energy: -36.39 kcal/mol
Frequency: 0.2784
Diversity: 2.58
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((((((((.((.((((((((((((.(.......).)))))))))))))).))).)))))))..
Thermodynamic Ensemble Prediction
...((((((((((.((.((((((((((((.(.......).)))))))))))))).)))},))))))..
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with the mir-139 being downregulated 24 hours post-injury in skin wounds compared to unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A systematic review of studies in human, mouse, rat, and pig models demonstrated that the mir-139 is the most significantly downregulated miRNA in skeletal muscle within 24 hours postmortem [Cianci et al. DOI:10.3390/ijms25158185]. Furthermore, the mir-139 is also cited as a specific marker for skin and venous blood in forensic body fluid identification, highlighting its tissue-specific expression for determining the origin of biological evidence [Liu et al. DOI:10.1007/s00414-025-03656-2].