Basic Information

Symbol
hsa-mir-140
RNA class
miRNA miRNA hairpin
Alias
MIR140 MicroRNA 140 Hsa-MiR-140-3p Hsa-MiR-140-5p Hsa-Mir-140 MIR-140 MIRN140 Hsa-Mir-140-P1-V1_pre Hsa-Mir-140-P1-V2_pre MIMAT0004597 MIMAT0000431 MI0000456 MiRNA140 SEDN
Location (GRCh38)
20:50585786-50585879
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-140
Sequence length
100 nt
GC content
0.5400

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-54.40 kcal/mol
Thermodynamic ensemble
Free energy: -55.79 kcal/mol
Frequency: 0.1047
Diversity: 6.37
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((.....((((((((((.(((((((((((((.(((((((.((.((...)))).))))))).))))))))))))))).)))))))).))))))).
Thermodynamic Ensemble Prediction
.(((((((.....((((((((((.(((((((((((((.(((((((.,({{....,.}),))))))).))))))))))))))).)))))))).))))))).
Forensic Context

A study in humans identified the mir-140 as significantly down-regulated in myocardial tissue from deceased septic patients compared to non-septic controls [Pasi Lehto et al. DOI:10.1038/s41598-024-81114-6]. A study in mice demonstrated that the mir-140 is detected in serum and is among the microRNAs profiled for radiation biodosimetry [Jacob et al. DOI:10.1371/journal.pone.0057603], while a review of rodent and human studies notes that the mir-140 is differentially expressed in the cortex of alcohol-dependent mice and is also identified as part of miRNA families altered in binge-drinking models [Mayfield DOI:10.1016/J.Alcohol.2017.01.004].