Basic Information

Symbol
hsa-miR-140-5p
RNA class
miRNA mature miRNA
Alias
hsa-miR-140 MIR140 MicroRNA 140
Location (GRCh38)
-
Forensic tag(s)
Cause of death analysis Forensic psychiatry evaluation Sudden death from CNS diseases
External database
miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-miR-140-5p
Sequence length
22 nt
GC content
0.4545
Forensic Context

A study in human myocardial autopsy specimens identified the miR-140-5p as down-regulated in septic hearts compared to non-septic controls, with differential expression analysis revealing 32 miRNAs with altered expression in sepsis [Pasi Lehto et al. DOI:10.1038/s41598-024-81114-6]. Research in humans and animal models has identified the miR-140-5p as a biomarker detected in the cerebellum and hippocampus of Alzheimer's disease patients [Das et al. DOI:10.1080/21655979.2021.2003667] and as a therapeutic target that regulates VEGF-A expression in experimental stroke models [Das et al. DOI:10.1080/21655979.2021.2003667].