Basic Information

Symbol
hsa-mir-141
RNA class
miRNA miRNA hairpin
Alias
MIR141 MicroRNA 141 Hsa-MiR-141-3p Hsa-MiR-141-5p Hsa-Mir-141 MIRN141 Hsa-Mir-8-P2b_pre MIMAT0000432 MIMAT0004598 MI0000457 Mir-141
Location (GRCh38)
19:53697533-53697617
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-141
Sequence length
95 nt
GC content
0.5579

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-49.00 kcal/mol
Thermodynamic ensemble
Free energy: -50.58 kcal/mol
Frequency: 0.0771
Diversity: 9.78
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((.((((.(((.(((((((((((.(((((((((((...((.......))...))).))))))))))))..)))))))..))))))).)))).
Thermodynamic Ensemble Prediction
.{(((.((((.(((.(((((((((((.(((((((((({.{.((.......)}..}}}),))))))))))))..)))))))..))))))).)))}.
Forensic Context

A study in humans demonstrated that the mir-141 was added to a microRNA panel to improve the discrimination of forensically relevant body fluids, including feces, menstrual and vaginal secretions, saliva, and urine, in DNA extracts [Rhodes et al. DOI:10.3390/genes14050968]. A review of the literature notes that the mir-141 has been reported as saliva-specific by some authors and as placental-specific in maternal plasma by others, and its expression can be up-regulated in plasma and serum in various cancers, indicating factors that may influence its reliability as a forensic biomarker [Silva et al. DOI:10.1016/J.Fsigen.2014.09.002].