Forensic Context

A study in humans demonstrated that the mir-142 is significantly decreased in the prefrontal cortex of depressed suicide subjects, with hsa-miR-142-5p and hsa-miR-142-3p showing expression levels of 0.635 and 0.642 of control, respectively [Smalheiser et al. DOI: 10.1371/journal.pone.0033201]. In forensic molecular biology, the mir-142 is also identified as a marker showing strongly increased expression in blood and menstrual secretion, used for body fluid identification via mathematical models like discriminant analysis [Courts et al. DOI: 10.3238/arztebl.m2024.0051]. A study in rats demonstrated that the mir-142 was significantly up-regulated in the corpus cavernosum following bilateral cavernous nerve crush injury, with its overexpression validated by quantitative real-time PCR [Liu et al. DOI:10.1016/j.jsxm.2018.05.006]. In human forensic science, the mir-142 was identified as a marker for venous blood, observed in all venous blood, semen, and saliva samples but not in menstrual blood, and was used within an 8-marker capillary electrophoresis system to differentiate body fluids [Mayes et al. DOI:10.1016/j.legalmed.2017.10.013].