Forensic Context

A study in human peripheral blood mononuclear cells demonstrated that miR-142-5p was significantly upregulated at a 1 Gy radiation dose, identifying it as a potential biomarker for radiation response [Lee et al. DOI:10.1155/2014/456323]. In a separate investigation of human postmortem prefrontal cortex, miR-142-5p was significantly decreased in depressed suicide subjects, with its expression measured at 0.635 of control levels [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. A study in rats demonstrated that the miR-142-5p was upregulated in whole blood two weeks after 15 Gy whole thorax irradiation, a finding verified by RT-qPCR [Gao et al. DOI:10.1038/srep44132]. In mice, the miR-142-5p was significantly decreased in serum 24 hours after 2 Gy total body irradiation, serving to distinguish irradiated from unirradiated animals [Acharya et al. DOI:10.1126/scitranslmed.aaa6593].