Basic Information

Symbol
hsa-mir-144
RNA class
miRNA miRNA hairpin
Alias
MIR144 MicroRNA 144 Hsa-MiR-144-3p Hsa-MiR-144-5p Hsa-Mir-144 MIRN144 Hsa-Mir-144-V1_pre Hsa-Mir-144-V2_pre MIMAT0000436 MIMAT0004600 MI0000460 Mir-144
Location (GRCh38)
17:28861533-28861618
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-144
Sequence length
86 nt
GC content
0.5000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-45.00 kcal/mol
Thermodynamic ensemble
Free energy: -45.46 kcal/mol
Frequency: 0.4744
Diversity: 4.01
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.(((((((.((((((.((((((((.(((((((((.((((......))))..))))))))))))))))).)))))).)))).)))..
Forensic Context

A study in human myocardial autopsy specimens demonstrated that the mir-144 was down-regulated in the hearts of patients deceased with sepsis compared to non-septic controls [Lehto et al. DOI:10.1038/s41598-024-81114-6]. In forensic human body fluid identification, the mir-144 lacked specific amplification in all non-blood samples, rendering it a solid marker for the general identification of blood, and it was successfully used in a decision algorithm to differentiate venous and menstrual blood [Sauer et al. DOI:10.1016/j.fsigen.2016.01.018]. A study in Wistar rats demonstrated that the mir-144 was upregulated in whole blood two weeks after 15 Gy whole thorax irradiation, a finding verified by RT-qPCR [Gao et al. DOI:10.1038/srep44132]. A separate review notes the mir-144 is an optimal miRNA that assists the biogenesis of its genomic neighbor, the suboptimal miR-451, in erythroid biology [Shang et al. DOI:10.1038/s41576-023-00611-y].