Basic Information

Symbol
hsa-mir-145
RNA class
miRNA miRNA hairpin
Alias
MIR145 MicroRNA 145 Hsa-MiR-145-5p Hsa-MiR-145-3p Hsa-Mir-145 MIR-145 MIRN145 Hsa-Mir-145_pre MIMAT0000437 MIMAT0004601 MI0000461 MiRNA145 hsa-mir-145a
Location (GRCh38)
5:149430646-149430733
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-145
Sequence length
88 nt
GC content
0.4773

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.10 kcal/mol
Thermodynamic ensemble
Free energy: -42.72 kcal/mol
Frequency: 0.0725
Diversity: 8.32
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.(((.((.(((((.((..((((,((.((((((((((((.,...........)))))))))))),)).))))..))))))).)).))).
Forensic Context

A study in humans identified hsa-miR-145 as a saliva-specific microRNA marker for forensic body fluid identification, demonstrating its high overexpression in saliva compared to other fluids with an area under the ROC curve of 0.97, indicating high diagnostic accuracy [Park et al. DOI:10.1002/elps.201400075]. A study in humans demonstrated that plasma extracellular vesicles containing the mir-145 were significantly upregulated in patients with acute coronary syndrome who experienced sudden cardiac death compared to healthy controls, and its levels were positively correlated with myoglobin, showing a predictive area under the curve of 0.7778 [Huang et al. DOI:10.1039/D2MO00257D].