Basic Information

Symbol
hsa-mir-146a
RNA class
miRNA miRNA hairpin
Alias
MIR146A MicroRNA 146a Hsa-MiR-146a-3p Hsa-MiR-146a-5p Hsa-Mir-146a Hsa-Mir-146 MIRN146A MIRN146 Hsa-Mir-146-P4_pre MicroRNA 146 MIMAT0004608 MIMAT0000449 MiRNA146A MI0000477 MiR-146a
Location (GRCh38)
5:160485352-160485450
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Wound age identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-146a
Sequence length
99 nt
GC content
0.4545

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.00 kcal/mol
Thermodynamic ensemble
Free energy: -40.79 kcal/mol
Frequency: 0.0548
Diversity: 6.43
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.((((((.(((((..((((((((((((.((.(((((.((.......))))))).)).)))))))))))).)))))))))))......))))).
Thermodynamic Ensemble Prediction
.(((((,((((((.(((((..((((((((((((.((.(((((.{(.......)}))))).)).)))))))))))).)))))))))))....,.))))).
Forensic Context

A study in humans demonstrated that the mir-146a was significantly decreased in the prefrontal cortex of depressed suicide subjects compared to non-psychiatric controls [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. In contrast, a review of human skin burn and wound healing found the mir-146a was downregulated in deep partial thickness burn skin four days post-injury and also downregulated in skin wounds 24 hours post-injury [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-146a acts as a negative regulator of TGF-β signaling in skeletal muscle after acute contusion, where its expression is reduced in a fibrotic model and by TGF-β treatment in C2C12 myotubes [Sun et al. DOI: 10.1093/abbs/gmx052].