Basic Information

Symbol
hsa-mir-146b
RNA class
miRNA miRNA hairpin
Alias
MIR146B MicroRNA 146b Hsa-Mir-146b MIRN146B Hsa-Mir-146-P1_pre Hsa-MiR-146b-5p Hsa-MiR-146b-3p MIMAT0002809 MIMAT0004766 MiRNA146B MI0003129 Mir-146b
Location (GRCh38)
10:102436512-102436584
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Mechanical injury analysis Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-146b
Sequence length
73 nt
GC content
0.5616

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-36.10 kcal/mol
Thermodynamic ensemble
Free energy: -37.67 kcal/mol
Frequency: 0.0785
Diversity: 7.72
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((.((((((.((((((((..(((((((((..((........))..).)))))))).)))))))))))))).))
Thermodynamic Ensemble Prediction
((.((((((.((((((((..(((((((((.,(,.,,....})}..)})))))))).)))))))))))))).))
Forensic Context

A study in human myocardial autopsy specimens from septic and non-septic deceased patients demonstrated that the mir-146b was significantly up-regulated in septic hearts, exhibiting the highest fold change among differentially expressed miRNAs [Pasi Lehto et al. DOI:10.1038/s41598-024-81114-6]. A study in rats demonstrated that the mir-146b was up-regulated more than 1.5-fold in the hippocampus at 1, 3, and 5 days following traumatic brain injury, identifying it as a potential marker for TBI progression [Sun et al. DOI:10.1007/s11596-014-1313-1]. In human and mouse studies, the mir-146b was downregulated in peripheral blood of antidepressant responders and upregulated in the ventrolateral prefrontal cortex of depressed suicide completers, establishing it as a biomarker of antidepressant response and a regulator of MAPK/Wnt signalling pathways [Lopez et al. DOI:10.1038/ncomms15497].