Basic Information

Symbol
hsa-mir-148a
RNA class
miRNA miRNA hairpin
Alias
MIR148A MicroRNA 148a Hsa-MiR-148a-5p Hsa-MiR-148a-3p Hsa-Mir-148a Hsa-Mir-148 MicroRNA 148 MIRN148A MIRN148 Hsa-Mir-148-P1_pre MIMAT0004549 MIMAT0000243 MI0000253 Mir-148a
Location (GRCh38)
7:25949919-25949986
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-148a
Sequence length
68 nt
GC content
0.4559

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-27.90 kcal/mol
Thermodynamic ensemble
Free energy: -28.73 kcal/mol
Frequency: 0.2595
Diversity: 2.55
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((((((((((.((((..(((((((.......))).))))))))..)).))))))))))))))
Thermodynamic Ensemble Prediction
((((((((((((((((.((((..(((((((.......))),})))))))..)).))))))))))))))
Forensic Context

A study in humans identified the mir-148a as differentially expressed in whole blood of patients with coronary artery disease who experienced recurrent myocardial infarction after percutaneous coronary intervention, where it was downregulated and associated with atherosclerosis and the inhibition of proinflammatory cytokines [Onuoha et al. DOI:10.1111/cts.13307]. In a separate human study on deep burn wounds, the mir-148a was found to be downregulated in denatured dermis compared to normal skin, with a fold change of 0.4423, as part of a broader miRNA profiling analysis of wound healing [Liang et al. DOI:10.1016/j.burns.2011.10.014]. Another study in humans demonstrated that the mir-148a was significantly down-regulated in the serum of patients with obstructive sleep apnea syndrome (OSAS) and was part of a four-miRNA diagnostic panel that achieved an AUC of 0.955 for OSAS screening [Mo et al. DOI:10.2147/NSS.S382765].