Basic Information

Symbol
hsa-let-7b
RNA class
miRNA miRNA hairpin
Alias
MIRLET7B MicroRNA Let-7b Hsa-Let-7b-3p Hsa-Let-7b-5p Hsa-Let-7b MIRNLET7B Hsa-Let-7-P2b2_pre MIMAT0000063 MIMAT0004482 MI0000063 Let-7b LET7B
Location (GRCh38)
22:46113686-46113768
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-let-7b
Sequence length
83 nt
GC content
0.5301

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-46.70 kcal/mol
Thermodynamic ensemble
Free energy: -48.39 kcal/mol
Frequency: 0.0641
Diversity: 7.68
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.(((((((((((((((((((((((.((((((.....))))))...))).....)))))))))))))))))))))))))
Thermodynamic Ensemble Prediction
(((((.(((((((((((((((((((((((,((((((.....)))))).,.,}}....})))))))))))))))))))))))))
Forensic Context

A study in humans identified 69 differentially expressed microRNAs in the whole blood of severely injured trauma patients, with let-7b showing a strong direct correlation with TLR3 gene expression (P < .0004; rho = 0.83) and direct correlations with clinical parameters including arterial blood gas HCO3 and base deficit [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. In a separate forensic investigation of sudden infant death syndrome (SIDS), hsa-let-7b was significantly upregulated in the brainstem tissue of SIDS cases compared to controls (p = .04), demonstrating its measurable dysregulation in archived formalin-fixed, paraffin-embedded tissues [Courts et al. DOI:10.1016/j.forsciint.2013.02.032].