Basic Information

Symbol
hsa-mir-148b
RNA class
miRNA miRNA hairpin
Alias
MIR148B MicroRNA 148b Hsa-MiR-148b-5p Hsa-MiR-148b-3p Hsa-Mir-148b MIRN148B Hsa-Mir-148-P4_pre MIMAT0004699 MIMAT0000759 MI0000811 Mir-148b
Location (GRCh38)
12:54337216-54337314
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-148b
Sequence length
99 nt
GC content
0.4343

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.20 kcal/mol
Thermodynamic ensemble
Free energy: -32.90 kcal/mol
Frequency: 0.0633
Diversity: 5.85
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......((..(((.((((((((((((((((((.((.((((..((((.............)))))))).)).)))))))))))))))))).))).))..
Thermodynamic Ensemble Prediction
.......((..(((.((((((({((((((((((.((.((((..((((..,,....,,,..)))))))).)).))))))))))}))))))).))).))..
Forensic Context

A study in humans demonstrated that the mir-148b was significantly decreased in the prefrontal cortex of depressed suicide subjects compared to non-psychiatric controls [Smalheiser et al. DOI:10.1371/journal.pone.0033201]. In a separate human study of severely injured trauma patients, the mir-148b showed an indirect correlation with TLR3 gene expression in peripheral whole blood [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. A study in mice demonstrated that the mir-148b showed differential expression after radiation injury in C3H/HeJ mice [Martello et al. DOI:10.1667/RADE-23-00007.1]. In human postmortem brain studies, the mir-148b was downregulated in BA9 of major depressive disorder suicide subjects and correlated with DNMT3b protein expression [Yoshino and Dwivedi DOI:10.3389/fpsyt.2020.543893].