Basic Information

Symbol
hsa-mir-149
RNA class
miRNA miRNA hairpin
Alias
MIR149 MicroRNA 149 Hsa-MiR-149-3p Hsa-MiR-149-5p Hsa-Mir-149 MIRN149 Hsa-Mir-149_pre MIMAT0004609 MIMAT0000450 MI0000478 Mir-149
Location (GRCh38)
2:240456001-240456089
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Tissue/body fluid identification Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-149
Sequence length
89 nt
GC content
0.7191

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-56.00 kcal/mol
Thermodynamic ensemble
Free energy: -56.75 kcal/mol
Frequency: 0.2956
Diversity: 3.93
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((((.(((.(.(.((((((.(((((.(((((.(.(((....))).))))))))))).)))))).).).))).)))).))))).
Thermodynamic Ensemble Prediction
.(((((((((.(((.(.(.((((((.(((((.(((((.(.(((....))).})))))))))).)))))).).).))).)))).))))).
Forensic Context

A study in humans demonstrated that the hsa-mir-149 rs2292832T/C single nucleotide polymorphism was evaluated as a candidate biomarker for sepsis susceptibility in patients with major blunt trauma, but no significant association with sepsis morbidity rate or multiple organ dysfunction scores was found in the screening cohort [Zhang et al. DOI:10.1097/SLA.0000000000000687]. A review of human skin burns and wound healing reported that hsa-miR-149-5p was downregulated in venous ulcers compared to normal skin and acute wounds and was also downregulated 24 hours post-injury in skin wounds versus unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A review of forensic miRNA applications in humans indicates that the mir-149 is considered a placental-specific biomarker, found at higher concentrations in maternal plasma before delivery [Silva et al. DOI:10.1016/J.Fsigen.2014.09.002].