Basic Information

Symbol
hsa-mir-15a
RNA class
miRNA miRNA hairpin
Alias
MIR15A MicroRNA 15a Hsa-MiR-15a-3p Hsa-MiR-15a-5p Hsa-Mir-15a MIRN15A Hsa-Mir-15-P1a_pre MIMAT0000068 MIMAT0004488 MI0000069 MiRNA15A Mir-15a
Location (GRCh38)
13:50049119-50049201
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-15a
Sequence length
83 nt
GC content
0.4217

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-30.50 kcal/mol
Thermodynamic ensemble
Free energy: -32.05 kcal/mol
Frequency: 0.0811
Diversity: 5.89
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((.......(..((((((((..((((((((({..(({....}),.))))))))))..))))))))..).......)))))
Forensic Context

A study in human deep burn patients identified 66 differentially expressed miRNAs in denatured dermis, with the mir-15a being up-regulated 2.42-fold compared to normal skin [Liang et al. DOI:10.1016/j.burns.2011.10.014]. Separately, in human plasma from young acute coronary syndrome patients, the mir-15a was significantly down-regulated 7-fold in ST-segment elevation myocardial infarction cases and demonstrated diagnostic utility with an area under the curve of 0.796 for discriminating patients from healthy controls [Tong et al. DOI:10.3390/ijms19051467]. A systematic review of studies in rats, mice, and humans identified aberrant expression profiles of 25 microRNAs, including the mir-15a, in diabetes associated with male reproductive complications [Latifi et al. DOI:10.1007/s11033-024-10197-1]. A separate review on microRNA biogenesis notes the mir-15a is a suboptimal miRNA whose biogenesis within the mir-15a/16 cluster is enhanced by auxiliary factors like SAFB1/2 and ERH [Shang et al. DOI:10.1038/s41576-023-00611-y].