Basic Information

Symbol
hsa-mir-150
RNA class
miRNA miRNA hairpin
Alias
MIR150 MicroRNA 150 Hsa-MiR-150-5p Hsa-MiR-150-3p Hsa-Mir-150 MIRN150 Hsa-Mir-150_pre MIMAT0000451 MIMAT0004610 MI0000479 MiRNA150 Mir-150
Location (GRCh38)
X:134541341-134541437
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-150
Sequence length
84 nt
GC content
0.6667

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-57.80 kcal/mol
Thermodynamic ensemble
Free energy: -58.61 kcal/mol
Frequency: 0.2701
Diversity: 3.26
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((.((((((((((((((..(((.(((((((.((((....))).).))))))))))..)))))))))))).)))))))).
Thermodynamic Ensemble Prediction
.((((((.((((((((((((((..(({{(((((((.((((....))).).))))))))))..)))))))))))).)))))))).
Forensic Context

A study in humans demonstrated that the mir-150 was lowly expressed and did not show the expected specificity for peripheral blood identification when evaluated as a body fluid-specific miRNA marker [Li et al. DOI:10.1016/j.fsigen.2024.103180]. A study in mice demonstrated that the mir-150 exhibits a radiation dose-dependent decrease in serum and whole blood, serving as the radiation-sensitive analyte in a biodosimetry assay with a dose resolution of ±0.5 Gy in the 0.5 to 3.5 Gy gamma ray range [Yadav et al. DOI:10.1126/scitranslmed.aaw5831]. In human studies, plasma levels of the mir-150 were found to be substantially lower in patients with atrial fibrillation, showing approximately 17-fold and 20-fold reductions in paroxysmal and persistent AF, respectively, and its reduced expression was independently associated with the disease [Liu et al. DOI:10.1371/journal.pone.0044906].