Forensic Context

A study in human postmortem formalin-fixed paraffin-embedded brain tissue demonstrated that the miR-153-3p was initially selected as a potential candidate marker based on a literature review but was not among the final three miRNAs studied in the entire cohort of fatal traumatic brain injuries [Bonin et al. DOI:10.3390/ijms241310836]. A separate review noted that the miR-153-3p is a therapeutic target whose downregulation induces angiogenesis via HIF-1alpha/VEGF-A/Notch signaling in ischemia and is detected in brain tissue of Alzheimer's disease patients [Das et al. DOI:10.1080/21655979.2021.2003667].