Forensic Context

A study in humans demonstrated that the miR-153-5p was significantly down-regulated in the nucleus accumbens of methamphetamine-sensitized mice, indicating its involvement in neuronal development, plasticity, and addiction processes [Xu et al. DOI:10.1007/S10571-023-01323-X]. In a separate investigation, chronic alcohol exposure in mice led to the downregulation of the miR-153-5p in hippocampal tissue, where it was identified as part of a regulatory network linked to neurodegeneration [Du et al. DOI:10.3389/Fphar.2024.1377501].