Basic Information

Symbol
hsa-mir-1537
RNA class
miRNA miRNA hairpin
Alias
MIR1537 MicroRNA 1537 Hsa-Mir-1537 Hsa-MiR-1537-3p MIRN1537 Hsa-MiR-1537-5p MIMAT0026765 MIMAT0007399 MI0007258 Mir-1537
Location (GRCh38)
16:69565808-69565868
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1537
Sequence length
61 nt
GC content
0.4098

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-28.40 kcal/mol
Thermodynamic ensemble
Free energy: -28.78 kcal/mol
Frequency: 0.5381
Diversity: 1.05
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A review of the literature indicates that the mir-1537 positively associates with PCB levels and cadmium exposure in human term placentas [Miguel et al. DOI:10.1089/Ars.2017.7175]. A study in mice demonstrated that methamphetamine-induced locomotor sensitization involves significant downregulation of mature miRNAs, including the mir-1537, in the nucleus accumbens, alongside decreased Ago2 and increased Dicer1 expression, indicating disrupted miRNA biogenesis as a key mechanism in addiction [Liu et al. DOI:10.1111/Adb.12616].