Forensic Context

A review of the literature indicates that the mir-1537 positively associates with PCB levels and cadmium exposure in human term placentas [Miguel et al. DOI:10.1089/Ars.2017.7175]. A study in mice demonstrated that methamphetamine-induced locomotor sensitization involves significant downregulation of mature miRNAs, including the mir-1537, in the nucleus accumbens, alongside decreased Ago2 and increased Dicer1 expression, indicating disrupted miRNA biogenesis as a key mechanism in addiction [Liu et al. DOI:10.1111/Adb.12616].