A study in mice demonstrated that the mir-154 is upregulated in brain tissue biopsy at 24 hours and 7 days following mild traumatic brain injury, identifying it as a potential biomarker [Martinez & Peplow DOI:10.4103/1673-5374.219025]. In human postmortem brain studies, the mir-154 was found to be downregulated in the prefrontal cortex of subjects with both schizophrenia and bipolar disorder [Yoshino & Dwivedi DOI:10.3389/fpsyt.2020.543893].