Basic Information

Symbol
hsa-mir-155
RNA class
miRNA miRNA hairpin
Alias
MIR155 MicroRNA 155 Hsa-Mir-155 Hsa-MiR-155-3p MIRN155 Hsa-Mir-155_pre Hsa-MiR-155-5p MIMAT0004658 MIMAT0000646 MI0000681 MiRNA155 Mir-155
Location (GRCh38)
21:25573980-25574044
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-155
Sequence length
65 nt
GC content
0.4000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.50 kcal/mol
Thermodynamic ensemble
Free energy: -29.82 kcal/mol
Frequency: 0.5912
Diversity: 1.56
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
((((((((((((((.(((.((((((((.(((....)))..)))))))))))))))))))))))))
Forensic Context

A study in human traumatic brain injury (TBI) cases demonstrated that the mir-155 is upregulated in postmortem brain tissue from deceased subjects compared to non-traumatic controls, indicating its diagnostic potential for TBI [Consalvo et al. DOI:10.3390/ijms25179539]. A study in humans demonstrated that the mir-155 is a promoter of inflammatory responses, promoting heat stress-induced inflammatory responses in microglia by increasing NF-kB pathway activation [Li et al. DOI:10.3389/fimmu.2021.624753]. In forensic cause-of-death determination, the mir-155 plays a critical role in inflammation, immunity, and cardiovascular disease, where highly expressed miR-155 can exacerbate myocardial injury in viral myocarditis, and a specific polymorphism (rs72014506 in MIR155HG) is associated with the risk of sudden cardiac death in human myocardium [Li et al. DOI:10.1093/fsr/owad003].