Basic Information

Symbol
hsa-mir-17
RNA class
miRNA miRNA hairpin
Alias
MIR17 MicroRNA 17 Hsa-MiR-17-3p Hsa-MiR-17-5p Hsa-Mir-17 MIRN17 Hsa-Mir-17-P1a_pre MIMAT0000070 MIMAT0000071 MI0000071 MIR17-5p MiR17-3p MiRNA17 MiRNA91 MIRN91 MiR-17 MIR91
Location (GRCh38)
13:91350605-91350688
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-17
Sequence length
84 nt
GC content
0.4286

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-33.80 kcal/mol
Thermodynamic ensemble
Free energy: -34.93 kcal/mol
Frequency: 0.1588
Diversity: 4.80
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
((((..(((((((..((((((((.((.(((({,(((((.......)).)))))))).)).))))))))...)))))))..))))
Forensic Context

A study in human peripheral blood mononuclear cells demonstrated that hsa-miR-17-5p was upregulated at 1 Gy of fractionated radiation exposure [Lee et al. DOI:10.1155/2014/456323]. In human skin, the mir-17 was downregulated four days post-burn in deep partial thickness burn skin versus normal skin and was also downregulated in burn hypertrophic scar and its derived fibroblasts compared to normal fibroblasts [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the mir-17 is down-regulated in all seven investigated aging models, including replicative senescence of endothelial, renal, and skin cells as well as organismal aging in mesenchymal stem cells, foreskin, and T-cell populations [Hackl et al. DOI:10.1111/j.1474-9726.2010.00549.x]. This down-regulation was validated by qPCR, showing up to 6-fold decreases, and correlated with increased mRNA levels of the target gene p21/CDKN1A, establishing it as a novel marker of cell aging.