Forensic Context

A study in human peripheral blood mononuclear cells demonstrated that the miR-17-5p is upregulated at a 1 Gy radiation dose and cooperates with miR-20b-5p, with predicted interactions to downregulate target genes including MCL1 and FGL2 and enrichment in pathways such as the pentose phosphate and thyroid cancer pathways [Lee et al. DOI:10.1155/2014/456323]. In a separate study on human plasma from young acute coronary syndrome patients, the miR-17-5p was identified as consistently expressed in small RNA sequencing and was consequently used as a reference gene for quantitative reverse transcription-polymerase chain reaction normalization [Tong et al. DOI:10.3390/ijms19051467]. A study in humans demonstrated that the miR-17-5p was significantly upregulated in the prefrontal cortex of subjects with schizophrenia (fold-change 1.22) and bipolar disorder (fold-change 1.23) compared to non-psychiatric controls [Smalheiser et al. DOI:10.1371/journal.pone.0086469], and a separate study in humans found that the miR-17-5p was significantly upregulated in the plasma of patients with coronary artery disease [Zhong et al. DOI:10.1002/jcla.23020].