Basic Information

Symbol
hsa-mir-18a
RNA class
miRNA miRNA hairpin
Alias
MIR18A MicroRNA 18a Hsa-MiR-18a-5p Hsa-MiR-18a-3p Hsa-Mir-18a Hsa-Mir-18 MIRN18A MIRN18 Putative MicroRNA 17 Host Gene Protein Putative MicroRNA Host Gene 1 Protein Hsa-Mir-17-P2a_pre MIMAT0000072 MIMAT0002891 MicroRNA 18 MI0000072 C13orf25 MiRNA18A MIR17HG Mir-18a MIRHG1 MiR-18 MIR18 MIRH1
Location (GRCh38)
13:91350751-91350821
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-18a
Sequence length
71 nt
GC content
0.4507

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-21.10 kcal/mol
Thermodynamic ensemble
Free energy: -22.57 kcal/mol
Frequency: 0.0917
Diversity: 7.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((..((((.((((.(((.((((.(((((..(.....)..)).))))))).))).)))).))))..))))
Thermodynamic Ensemble Prediction
{(((..((((.((((.(((.((((.((({{..{,....,..)}.))))))).))).)))).))))..)))}
Forensic Context

A study in humans identified hsa-miR-18a* as a circulating miRNA with significantly increased levels in the plasma of acute myocardial infarction patients compared to healthy controls using next-generation sequencing, suggesting its potential as a biomarker for this condition [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. A study in rats demonstrated that isoproterenol injection induced cardiac injury, as evidenced by increased plasma troponin-I, and caused significant upregulation of the mir-18a in heart tissue, with a 6.48-fold increase observed one hour post-injection [Hosoya et al. DOI:10.1016/J.Legalmed.2024.102475].