Basic Information

Symbol
hsa-mir-181a-1
RNA class
miRNA miRNA hairpin
Alias
MIR181A1 MicroRNA 181a-1 Hsa-MiR-181a-3p Hsa-MiR-181a-5p Hsa-Mir-213 MicroRNA 213 MIRN181A1 MIRN213 Hsa-Mir-181-P1a_pre Hsa-Mir-181a-1 MIMAT0000270 MIMAT0000256 Mir-181a-1 MI0000289 Mir-213 MIR213
Location (GRCh38)
14:101026785-101026864
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-181a-1
Sequence length
110 nt
GC content
0.4182

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.90 kcal/mol
Thermodynamic ensemble
Free energy: -37.34 kcal/mol
Frequency: 0.0960
Diversity: 7.13
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((..((((((((((..((.(.(((.((((((..(((((((.((((.((.......)).))))))))))))))))).))).).))..))).)))).)))...))))..
Thermodynamic Ensemble Prediction
.((((..((((((((((..((.(.(((.((((((..(((((((.((((.({.......)).))))))))))))))))).))).).))..))).)))).)))...))))..
Forensic Context

A study in humans demonstrated that the SNP rs10760371 within miR-181a was nominally associated with methamphetamine use disorder with psychosis [Sun et al. DOI:10.1016/j.neulet.2019.134725]. A study in mice demonstrated that the mir-181a-1 was one of the top 20 most abundant known miRNAs in the thymus and was identified as part of the response to ionizing radiation-induced thymus injury [Chen et al. DOI:10.1080/09553002.2016.1207821]. In human plasma, the mir-181a-1 was significantly downregulated in patients with coronary artery disease, where it was associated with cardiometabolic gene regulation [Zhong et al. DOI:10.1002/jcla.23020].