Basic Information

Symbol
hsa-mir-181a-2
RNA class
miRNA miRNA hairpin
Alias
MIR181A2 MicroRNA 181a-2 Hsa-MiR-181a-2-3p Hsa-MiR-181a-5p Hsa-Mir-181a MIRN181A2 MIRN181A Hsa-Mir-181-P1b_pre Hsa-Mir-181a-2 MicroRNA 181a MIMAT0004558 MIMAT0000256 Mir-181a-2 MI0000269
Location (GRCh38)
9:124692442-124692551
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-181a-2
Sequence length
110 nt
GC content
0.5000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-53.70 kcal/mol
Thermodynamic ensemble
Free energy: -54.76 kcal/mol
Frequency: 0.1794
Diversity: 6.72
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((((....)))...))))).(((((((((((((.(((.((((((..(((((((.((((...........))))))))))))))))).))).))))))))))))).
Thermodynamic Ensemble Prediction
.((((((((....}}}.,,))))).(((((((((((((.(((.((((((..(((((((.((((...........))))))))))))))))).))).))))))))))))).
Forensic Context

A study in humans demonstrated that the mir-181a-2 was significantly downregulated in the plasma of patients with coronary artery disease compared to normal coronary artery controls, as identified by RNA sequencing and validated by qRT-PCR [Zhong et al. DOI:10.1002/jcla.23020]. In mice, the mir-181a-2 was identified as one of the top 20 most abundant known miRNAs in thymus tissue, and its expression profile was characterized in response to ionizing radiation-induced injury [Chen et al. DOI:10.1080/09553002.2016.1207821]. A study in rhesus macaques demonstrated that the mir-181a-2 was utilized as a feature in elastic net-based models to predict radiation dose, specifically within serum samples collected at Day 6 and Day 15 post whole thorax irradiation [May et al. DOI:10.1038/s41598-022-16316-x].