Forensic Context

A study in humans demonstrated that the miR-181a-5p is upregulated in saliva from patients with mild traumatic brain injury (mTBI) and is associated with specific signaling pathways [Matyasova et al. DOI:10.4149/gpb_2021038]. Another study in humans found that the miR-181a-5p is downregulated in plasma from young patients with ST-segment elevation myocardial infarction (STEMI) as identified by small RNA sequencing [Tong et al. DOI:10.3390/ijms19051467]. A study in rhesus macaques demonstrated that the relative abundance of the miR-181a-5p in plasma at day 15 post whole thorax lung irradiation correlated with survival time, identifying it within an eleven-miRNA panel predictive of survival [Rogers et al. DOI:10.1667/RADE-21-00043.1]. In humans, the miR-181a-5p was mentioned as being upregulated in congestive heart failure in a previous study, though it was not experimentally investigated in the provided coronary artery disease research [Zhong et al. DOI:10.1002/jcla.23020].