Basic Information

Symbol
hsa-mir-181b-1
RNA class
miRNA miRNA hairpin
Alias
MIR181B1 MicroRNA 181b-1 Hsa-MiR-181b-5p Hsa-MiR-181b-3p Hsa-Mir-181b-1 MIRN181B1 Hsa-Mir-181-P2a_pre MIMAT0000257 MIMAT0022692 Mir-181b-1 MI0000270 hsa-mir-181b-12
Location (GRCh38)
14:101059755-101059838
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-181b-1
Sequence length
110 nt
GC content
0.4455

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-33.20 kcal/mol
Thermodynamic ensemble
Free energy: -35.24 kcal/mol
Frequency: 0.0362
Diversity: 10.60
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.........................(((((((.....(((((((((...((((((((((....(((....))))))))))))).)))))))))....)))))))......
Thermodynamic Ensemble Prediction
........{{{{....,}}},....(((((((.....(((((((((...((((((((((,..{,....}..)})))))))))).)))))))))....)))))))......
Forensic Context

A study in humans demonstrated that the mir-181b was investigated as a potential peripheral biomarker for methamphetamine use disorder with psychosis, where its expression in venous blood leukocytes showed no significant difference between patients and controls (P = 0.151) [Sun et al. DOI:10.1016/j.neulet.2019.134725]. A study in mice demonstrated that the mir-181b is upregulated in exosomes from lean adipose tissue macrophages (ExosLean) and targets Bcl2l11/Bim to reprogram M1 to M2 macrophage polarization, accelerating diabetic wound healing [Wang et al. DOI:10.1007/s00438-024-02183-w]. In human postmortem brain studies, the mir-181b was found upregulated in the BA9 and superior temporal gyrus of subjects with schizophrenia, where its biogenesis is perturbed and it regulates VSNL1 and GRIA2 [Yoshino et al. DOI:10.3389/fpsyt.2020.543893].