Basic Information

Symbol
hsa-mir-181b-2
RNA class
miRNA miRNA hairpin
Alias
MIR181B2 MicroRNA 181b-2 Hsa-MiR-181b-5p Hsa-Mir-181b-2 MIRN181B2 Hsa-Mir-181-P2b_pre Hsa-MiR-181b-2-3p MIMAT0031893 MIMAT0000257 Mir-181b-2 MI0000683 hsa-mir-181b-12
Location (GRCh38)
19:53707453-53707539
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-181b-2
Sequence length
89 nt
GC content
0.4607

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.70 kcal/mol
Thermodynamic ensemble
Free energy: -35.85 kcal/mol
Frequency: 0.1554
Diversity: 3.17
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
....((((((((.....(((((((((..(((((((((({{((.......)))))))))))))))))))))).....))))).)))....
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific miRNAs like the mir-181b-2 being upregulated 6 hours post-burn in heat-shocked skin epidermal stem cells versus controls [Siu et al. DOI:10.1111/wrr.13100]. In a separate human study on heart failure, hsa-miR-181b-3p expression was investigated as a potential biomarker for sacubitril/valsartan resistance, though its qRT-PCR validation results were inconsistent with initial microarray data [Su et al. DOI:10.1016/j.ejphar.2023.175547]. A study in humans demonstrated that the mir-181b-2 was significantly downregulated in patients with coronary artery disease compared to normal coronary artery controls, as identified through RNA sequencing and validated by qRT-PCR [Zhong et al. DOI:10.1002/jcla.23020]. In mice, the mir-181b-2 was identified as one of the top 20 most abundant known miRNAs in the thymus, and its expression profile was characterized in response to ionizing radiation-induced injury [Chen et al. DOI:10.1080/09553002.2016.1207821].