Forensic Context

A study in humans demonstrated that the miR-181b-5p is downregulated in plasma from young patients with ST-segment elevated myocardial infarction (STEMI) compared to healthy controls as identified by small RNA sequencing [Tong et al. DOI:10.3390/ijms19051467]. A study in humans identified the miR-181b-5p as significantly downregulated in coronary artery disease patients compared to normal coronary artery controls, classifying it as a potential biomarker for the condition [Zhong et al. DOI:10.1002/jcla.23020]. A review of thermal-induced skin injury in humans, rats, and mice documented that the miR-181b-5p regulates apoptosis and proliferation in hypertrophic scar fibroblasts via the MEK/ERK/p21 pathway, indicating its role in scar formation [Wang et al. DOI:10.1007/s00438-024-02183-w].