Basic Information

Symbol
hsa-mir-181c
RNA class
miRNA miRNA hairpin
Alias
MIR181C MicroRNA 181c Hsa-MiR-181c-5p Hsa-MiR-181c-3p Hsa-Mir-181c MIRN181C Hsa-Mir-181-P1c_pre MIMAT0000258 MIMAT0004559 MI0000271 Mir-181c
Location (GRCh38)
19:13874699-13874808
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-181c
Sequence length
110 nt
GC content
0.5455

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-45.20 kcal/mol
Thermodynamic ensemble
Free energy: -46.88 kcal/mol
Frequency: 0.0652
Diversity: 16.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((.......(((..(((((.((((..((((((((..(((((((.(((((...........)))))))))))).))))))))..)))).))))))))........))).
Thermodynamic Ensemble Prediction
.(((.......((,.((((((.((((..((((((((..(((((((.(((((..,......,.)))))))))))).))))))))..)))).))))))))........))).
Forensic Context

A study in Sprague-Dawley rats and NRK-52E cells demonstrated that the mir-181c was significantly suppressed in kidney tissue after burn injury and further downregulated during burn sepsis, while its ectopic expression reduced LPS-induced TLR4 protein expression, suppressed KIM-1 mRNA, and inhibited inflammatory and chemokine gene expression, ultimately attenuating burn sepsis-induced acute kidney injury [Yu et al. DOI:10.007/s00068-022-02124-5].