Forensic Context

A study in humans identified the miR-181c-5p as upregulated in saliva from patients with mild traumatic brain injury (mTBI) and found it targets 1798 genes, with its signaling pathways overlapping across serum, plasma, and saliva [Matyasova et al. DOI:10.4149/gpb_2021038]. Another human study of severe trauma patients with bone fractures found the miR-181c-5p was downregulated in plasma-derived exosomes from male patients compared to operative controls, noting its involvement in hematopoiesis [Munley et al. DOI:10.1097/TA.0000000000004225].