Basic Information

Symbol
hsa-mir-181d
RNA class
miRNA miRNA hairpin
Alias
MIR181D MicroRNA 181d Hsa-MiR-181d-5p Hsa-Mir-181d MIRN181D Hsa-Mir-181-P2c_pre Hsa-MiR-181d-3p MIMAT0026608 MIMAT0002821 MI0003139 Mir-181d
Location (GRCh38)
19:13874875-13875011
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Individual identification
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-181d
Sequence length
137 nt
GC content
0.5985

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-68.10 kcal/mol
Thermodynamic ensemble
Free energy: -70.60 kcal/mol
Frequency: 0.0174
Diversity: 9.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((((((((((...(((..(((((((....(((((((((....((((((((((.((.(........)))))))))))))..)))))))))...))))))).))).......))))).))))))..))))))
Thermodynamic Ensemble Prediction
(((((((((((((((((...(((.,(((((((....(((((((((.,,.((((((((((.{(.(........))}))))))))))..)))))))))...))))))).))).......))))),})))))..))))))
Forensic Context

A study in humans demonstrated that circulating hsa-miR-181d was significantly increased in the plasma of male acute myocardial infarction patients compared to healthy controls, as identified by next-generation sequencing [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. A separate human study on cord blood hematopoietic stem cells from twins found that the mir-181d showed high expression differences in fraternal twins and low differences in identical twins, with its expression influenced by both genetic and environmental factors and targeting the BCL2 gene [Ajami et al. DOI:10.22074/cellj.2019.5683].