Forensic Context

A study in human cadavers demonstrated that serum exosomes and their miRNA cargo, including the miR-101-5p, remain stable for at least three days when stored at or below 20°C [Kanno et al. DOI:10.1007/S00414-022-02913-Y]. Separately, a study in young human patients with acute coronary syndrome (ACS) identified the miR-101-5p as upregulated in plasma via small RNA sequencing in STEMI patients [Tong et al. DOI:10.3390/ijms19051467]. A study in humans demonstrated that the miR-101-5p is a high diagnostic performance circulating microRNA, showing up-regulation during acute myocardial infarction followed by a decline after revascularization [Wang et al. DOI:10.1186/s40364-024-00690-x].