Basic Information

Symbol
hsa-mir-182
RNA class
miRNA miRNA hairpin
Alias
MIR182 MicroRNA 182 Hsa-MiR-182-5p Hsa-MiR-182-3p Hsa-Mir-182 MiR-182 MIRN182 Hsa-Mir-96-P2_pre MIMAT0000260 MIMAT0000259 MI0000272 MiRNA182
Location (GRCh38)
9:123402525-123402603
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Sudden death from CNS diseases Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-182
Sequence length
110 nt
GC content
0.5727

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.60 kcal/mol
Thermodynamic ensemble
Free energy: -49.37 kcal/mol
Frequency: 0.0569
Diversity: 9.30
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((.(((((.((((((..(((((((...((((((...((((((..............))))))))))))...)))))))..)))))).)))).)..)).))))..
Thermodynamic Ensemble Prediction
..((((((.{((((.((((((..(((((((...((((((...((((((........,.....))))))))))))...)))))))..)))))).)))).}..))}})))..
Forensic Context

A study in humans demonstrated that the mir-182 is highly overexpressed in blood and shows high sensitivity and specificity for forensic body fluid identification, with an area under the curve (AUC) of approximately 1 [Park et al. DOI:10.1002/elps.201400075]. A separate study in humans investigating acute spinal cord injury found that the mir-182 is significantly downregulated in patient plasma at emergency room admission and shows stronger suppression compared to polytrauma patients without neurotrauma, with its expression correlating negatively with neurological impairment [Hörauf et al. DOI:10.3390/ijms262210954]. A study in rats demonstrated that the mir-182 was the most affected microRNA in skeletal muscle, showing a 12.81-fold upregulation in burn, a 23.83-fold upregulation in hindlimb unloading, and an additive 35.35-fold upregulation in combined burn and hindlimb unloading groups without exercise, while exercise training in the combined injury group led to a 7.8-fold decrease [Song et al. DOI:10.1097/BCR.0000000000000444].