Forensic Context

A study in humans demonstrated that the miR-182-5p was significantly downregulated in plasma from patients with acute spinal cord injury (SCI) compared to healthy controls, and this suppression was stronger in SCI than in polytrauma patients without neurotrauma, with its expression also correlating negatively with neurological impairment [Hörauf et al. DOI:10.3390/ijms262210954]. In a separate forensic investigation, the miR-182-5p was evaluated as a body fluid-specific marker for peripheral blood identification but was found to be lowly expressed and did not show the expected specificity in human samples, and it was not among the 12 key features selected for the final multi-class support vector machine classification model [Li et al. DOI:10.1016/j.fsigen.2024.103180]. A review of human studies on multi-omics biological age estimation identified the miR-182-5p as a top list gene associated with 11 epigenetic aging clocks [Solovev et al. DOI:10.1016/j.mad.2019.111192].