Basic Information

Symbol
hsa-mir-183
RNA class
miRNA miRNA hairpin
Alias
MIR183 MicroRNA 183 Hsa-MiR-183-5p Hsa-MiR-183-3p Hsa-Mir-183 MIRN183 Hsa-Mir-96-P3-V1_pre Hsa-Mir-96-P3-V2_pre MIMAT0000261 MIMAT0004560 MI0000273 MiRNA183 MiR-183
Location (GRCh38)
7:127058088-127058184
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis Wound age identification Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-183
Sequence length
110 nt
GC content
0.4909

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.20 kcal/mol
Thermodynamic ensemble
Free energy: -44.40 kcal/mol
Frequency: 0.0056
Diversity: 13.36
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((..((.(.((.(((.((((((((.((((((.((((((..(((((((((((......)))..))))))))))))..)).)))))).))))))))))).)).)))..)).
Thermodynamic Ensemble Prediction
.((..(,,(.((.(({{((((((((.((((((.{(((((..(((((((((((......)))..)))))))))))),..}.)))))).))))))))))).)).}))..)).
Forensic Context

A study in young human patients with acute coronary syndrome demonstrated that plasma miR-183-5p was significantly up-regulated (8-fold) in NSTEMI patients and exhibited high discriminatory power for differentiating NSTEMI from healthy controls with an AUC of 0.917 [Tong et al. DOI:10.3390/ijms19051467]. In a separate study of severely injured human trauma patients, the mir-183 showed an indirect correlation with TLR4 gene expression [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. A study in mice demonstrated that the mir-183 was significantly upregulated in antemortem burned skin compared to intact and postmortem burned skin, with elevated expression detectable until 120 hours after death [Zhang et al. DOI:10.1080/20961790.2020.1719454].