Basic Information

Symbol
hsa-mir-103a-1
RNA class
miRNA miRNA hairpin
Alias
MIR103A1 MicroRNA 103a-1 Hsa-MiR-103a-3p Hsa-Mir-103a-1 Hsa-Mir-103-1 MicroRNA 103-1 MIRN103-1 MIR103-1 Hsa-Mir-103-P4_pre Hsa-MiR-103a-1-5p MIMAT0037306 MIMAT0000101 Mir-103a-1 MI0000109 hsa-mir-103-1
Location (GRCh38)
5:168560896-168560973
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-103a-1
Sequence length
78 nt
GC content
0.4872

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.00 kcal/mol
Thermodynamic ensemble
Free energy: -32.77 kcal/mol
Frequency: 0.0567
Diversity: 5.81
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((.((((((.((.(((((((((((.(((.(.(....).).)))))))))))))).))))))..)).))))...
Thermodynamic Ensemble Prediction
...((((.((((({{((.(((((((((({,(((.(.(....).).)))))))))))))).)))))}..)).))))...
Forensic Context

A meta-analysis in humans identified the mir-103a-1 as upregulated in serum following mild traumatic brain injury, where it targets 2087 genes and is part of a robust peripheral signaling signature involving MAPK, TGF-β, WNT, and other pathways that overlap across serum, plasma, and saliva [Matyasova et al. DOI:10.4149/gpb_2021038]. Separately, a study in young human patients with acute coronary syndrome found the mir-103a-1 upregulated in plasma via small RNA sequencing, identifying it as a potential diagnostic marker for this condition [Tong et al. DOI:10.3390/ijms19051467]. A study in mice demonstrated that the mir-103a-1 suppresses the expression of KCNH2 mRNA and protein, which is associated with long QT syndrome and sudden unexplained cardiac death [Lou et al. DOI:10.1016/j.jflm.2022.102332].