Basic Information

Symbol
hsa-mir-186
RNA class
miRNA miRNA hairpin
Alias
MIR186 MicroRNA 186 Hsa-MiR-186-3p Hsa-MiR-186-5p Hsa-Mir-186 MIRN186 Hsa-Mir-186_pre MIMAT0000456 MIMAT0004612 MI0000483 MiR-186
Location (GRCh38)
19:53701227-53701287
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-186
Sequence length
86 nt
GC content
0.3605

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.10 kcal/mol
Thermodynamic ensemble
Free energy: -42.86 kcal/mol
Frequency: 0.0573
Diversity: 5.47
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.(((({.(((((((((((((((((.((((((((((((...,..........))))))))))).)))))))))))))))))})))).
Forensic Context

A study in human infants demonstrated that the miRNA expression profile of gastric content from breast-fed infants was closer to breast milk than to formula-fed infants or adult gastric juice, with the mir-186 being significantly more abundant in breast milk and breast-fed infant gastric content compared to formula-fed infants and adult gastric juice, suggesting its potential as a biomarker for breast-feeding [Kakimoto et al. DOI:10.1007/S00414-019-02226-7]. In a separate investigation of human plasma from young acute coronary syndrome patients, the mir-186 was mentioned in the literature as having peak expression approximately ten hours after the onset of chest pain in patients with acute myocardial infarction [Tong et al. DOI:10.3390/ijms19051467]. In a separate human study, a serum miRNA profile including the mir-186 was identified as a diagnostic fingerprint for acute myocardial infarction and angina pectoris, where it was significantly upregulated in AMI patients compared to controls and showed significant differences between AMI and AP cases [Li et al. DOI:10.1186/1755-8794-6-16].