Forensic Context

A meta-analysis in humans identified the mir-103a-1 as upregulated in serum following mild traumatic brain injury, where it targets 2087 genes and is part of a robust peripheral signaling signature involving MAPK, TGF-β, WNT, and other pathways that overlap across serum, plasma, and saliva [Matyasova et al. DOI:10.4149/gpb_2021038]. Separately, a study in young human patients with acute coronary syndrome found the mir-103a-1 upregulated in plasma via small RNA sequencing, identifying it as a potential diagnostic marker for this condition [Tong et al. DOI:10.3390/ijms19051467]. A study in mice demonstrated that the mir-103a-1 suppresses the expression of KCNH2 mRNA and protein, which is associated with long QT syndrome and sudden unexplained cardiac death [Lou et al. DOI:10.1016/j.jflm.2022.102332].