Forensic Context

A study in human postmortem brain tissue demonstrated that the miR-19a-3p showed no statistically significant differences in expression levels between traumatic brain injury cases and controls [Consalvo et al. DOI:10.3390/ijms25179539]. In a separate human clinical study investigating coronary artery disease, the miR-19a-3p was differentially expressed in whole blood and was downregulated in patients with recurrent myocardial infarction, with associations noted for macrophage response and vascular disease [Onuoha et al. DOI:10.1111/cts.13307]. A study in rats demonstrated that the miR-19a-3p was upregulated in whole blood two weeks after 15 Gy whole thorax irradiation, a finding verified by RT-qPCR [Gao et al. DOI:10.1038/srep44132]. In forensic cause-of-death analysis, the miR-19a-3p was significantly increased in the peripheral blood mononuclear cells of individuals with major depressive disorder who died by suicide and was also identified as part of a network related to inflammatory response pathways [Song et al. DOI:10.1007/s00414-023-03091-1].