Basic Information

Symbol
hsa-mir-19b-1
RNA class
miRNA miRNA hairpin
Alias
MIR19B1 MicroRNA 19b-1 Hsa-MiR-19b-1-5p Hsa-MiR-19b-3p Hsa-Mir-19b-1 MIRN19B1 Putative MicroRNA 17 Host Gene Protein Putative MicroRNA Host Gene 1 Protein Hsa-Mir-19-P2a_pre MicroRNA-19b MIMAT0000074 MIMAT0004491 MiR-19b-1 MiRNA19B1 MI0000074 C13orf25 MIR17HG MiR-19b MIR19B MIRHG1 MIRH1 hsa-mir-19b
Location (GRCh38)
13:91351192-91351278
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-19b-1
Sequence length
87 nt
GC content
0.4368

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-38.50 kcal/mol
Thermodynamic ensemble
Free energy: -39.77 kcal/mol
Frequency: 0.1268
Diversity: 5.18
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((..(((((((((((((((((((((((((..((((.,.........,.)))))))))),)}.))))))))))))))))))))))
Forensic Context

A review of literature on alcohol-mediated dysregulation of microRNA expression in utero, synthesizing findings from multiple species, indicates that the mir-19b-1 is altered in plasma of pregnant ewes and newborn lambs after ethanol exposure [Mandal et al. DOI:10.1002/JAT.3504]. A separate study in mice demonstrated that therapeutic hypothermia recovers hypoxia-induced decreases in miR-483-3p expression, and its overexpression inhibits cardiomyocyte apoptosis and reduces infarct size by targeting Cdk9, improving cardiac function [Xue et al. DOI:10.1161/JAHA.122.026160].